Sep 24, 2022  
2021-2022 Academic Catalog 
    
2021-2022 Academic Catalog [Published Catalog]

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GHHE 000/5550 - Systems Neurobiology in Public Health (3 cr.)



Description
The systems biology approach to disease examines how the interaction between the biological entity and environmental stressors influence the components of a biological system, and how the interactions between these components result in changes in the function and behavior of that system. Systems biology integrates genomic, proteomic, and metabolomic technologies to construct models of complex biological systems and diseases. Together, these technologies allow us to interrogate and refine our knowledge of cellular processes. This course will use a systems biological perspective to detail the most recent findings that link the environmental to human neurological disease. The course will include an assessment of systems-based tools to evaluate environmental health risks, an overview of molecular pathways that are essential for cellular survival after exposure to environmental stressors, recent findings on gene-environment interactions influencing environmental agent-induced diseases, with a nervous system focus, and the development of computational methods to predict susceptibility to these environmental etiological factors. Environmental stressors relevant to human health and disease, high-throughput technologies, and biological pathways associated with compromised function are integrated with earlier coursework on molecular and cellular biology, toxicology, pathology, and computational biology.



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