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Apr 18, 2024
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GHHE 000/5340 - Principles of Toxicokinetics, Toxicodynamics, and Chemical Classes (3 cr.)
Description
This course is designed to introduce students to the kinetic (exposure, absorption, biotransformation, excretion) determinants of chemical bioavailability, as well as the dynamic (chemical-biological interaction) determinants of biological response and effect. A survey of the major classes of natural and manufactured chemicals exerting adverse effects are highlighted, as are the scientific advances, human genomics which have significant implications toxicology and gene-environment interactions. New experimental techniques and scientific paradigms that are based on our understanding of genes and their actions are rapidly proliferating in laboratories; thus, the students need to have a broad knowledge of metabolism, mechanisms and effects of toxicants, as well as to understand techniques that are available for their laboratory research. Thus, the material that is covered spans basics of biochemical processes that are affected by environmental agents, to molecular mechanisms of action, and to current experimental approaches in environmental sciences and toxicology.
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