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Dec 26, 2024
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GHHE 000/5530 - Neuroimmunology (3 cr.)
Description
Parallels are drawn between the nervous and immune systems in terms of the heterogeneity in cellular structure and intercellular signaling mechanisms. Recent evidence has brought to light the intimate relationship of the two systems in terms of nervous system regulation of immune system function and psychoimmunology. Long considered an immunoprivileged site, the nervous system is now recognized as a major target of immune activity during neurodegenerative disease, neuroinflammation and neurotoxicity. Both neurons and glia, including astrocytes, oligodendrocytes and Schwann cells, have been shown to elaborate and respond to immune mediators as well as being immune effectors in homeostasis and neurological disorders. The diagnostic and therapeutic potential of understanding these interactions will be explored through lectures, discussions of timely literature and class room engagement. permission of Instructor.
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