Mar 29, 2024  
2018-2019 Academic Catalog 
    
2018-2019 Academic Catalog [Published Catalog]

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GHHE 000/5470 - Nano-Enabled Precision Health (3 cr.)



Description
This course will discuss the opportunities and the challenges in developing Nanobiotechnology applications from the bench to the bed side where Nanomedicine can offer exciting prospects in diagnostics and therapeutics and their combinations in various diseases ranging from Cardiovascular, Vascular, Neurology, Inflammatory, infectious, dermatological, Ophthalmological, hematological and oncological diseases. For Nanotherapeutics, many biologically active compounds that have the desired activity in vitro never make it to the clinic because of poor solubility, malabsorption, instability, short half-life, poor safety profiles, and/or sub-optimal efficacy profiles. By encapsulating or binding such compounds with nanostructures, the fate of the compound in the body is determined by the characteristics of the nanostructure. By carefully designing and engineering the nanostructure properties we can improve target accumulation while avoiding toxicity-sensitive tissues. For some biological drugs, like non-coding RNAs, combination with a nanostructure appears even a requirement to cross the many barriers on its way to site of action. For these strategies, nanomedicine is an integral part of drug development in the treatment and early detection of various disorders. For Nano diagnostics, the small volume and extremely high surface area of nanoparticles offers attractive properties for binding specific diagnostic probes that provide functional information. For thoronstics, where diagnostics and therapeutics are combined, nanotechnology is an attractive proposition. This advanced topics in NanoMedicine will integrate practical know-how as to the impact of nanomedicine; real-world applications of Nanobiotechnology in biomedical research, therapeutics and diagnostics; and the familiarity with approaches to nanoformulation and drug-delivery; challenges of neglecting issues of nano-safety and nanoformulation efficacy; market demands, regulatory hurdles confronted by nanomedicine; familiarity with the social and economic impact of Nanobiotechnology on commercialization. This course provides opportunities for career advancement in research, production and professional practice, and frontiers in precision health.



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